• Gene Family Details



FAMILY INFORMATION


Family name Kunitz-P trypsin inhibitor (Kunitz)
Class Cys-rich
Mode of Action Peptidase inhibitor
Post-translational modifications (PTMs) 4 Cysteines
Receptor -
Evolutionary Range -
Function Inhibits Ser peptidases such as Trypsin, herbivory defense
References
  • Potato tuber protein proteinase inhibitors belonging to the Kunitz soybean inhibitor family Potato tuber protein proteinase inhibitors belonging to the Kunitz soybean inhibitor family Biochemistry (Mosc) . 1997 Dec;62(12):1367-74. Authors T A Valueva   1 ,  T A Revina ,  V V Mosolov Affiliation 1 Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia. PMID: 9481870 Abstract Three protein inhibitors of proteolytic enzymes with molecular weights 21, 22, and 23 kD were isolated from potato tubers (Solanum tuberosum L.) by ammonium sulfate precipitation followed by gel and ion-exchange chromatography. The 21- and 22-kD proteins were shown to be serine proteinase inhibitors with different specificities. The 21-kD protein inhibits human leucocyte elastase and trypsin effectively, but it is less effective towards chymotrypsin. The 22-kD protein is an inhibitor of cysteine proteinases and suppresses the activities of papain, ficin, and bromelain with the same affinities. None of the isolated proteins inhibit subtilisin, pepsin, or cathepsin D. The 21-kD protein consists of two disulfide-linked polypeptide chains with molecular weights of 16.5 +/- 1 kD and 4.5 +/- 1 kD. The 22-kD and 23-kD proteins have a single polypeptide chain. The N-terminal 22-25 amino acid sequences of these three proteins were determined. These sequences have significant homology to other plant inhibitors from the Kunitz soybean inhibitor superfamily. Publication types Research Support, Non-U.S. Gov't MeSH terms Amino Acid Sequence Chromatography, Ion Exchange Chymotrypsin / metabolism Electrophoresis, Polyacrylamide Gel Humans Leukocyte Elastase / antagonists & inhibitors Molecular Sequence Data Molecular Weight Sequence Homology, Amino Acid Solanum tuberosum / chemistry* Trypsin / metabolism Trypsin Inhibitor, Kunitz Soybean / chemistry Trypsin Inhibitor, Kunitz Soybean / isolation & purification Trypsin Inhibitor, Kunitz Soybean / metabolism* Substances Trypsin Inhibitor, Kunitz Soybean Chymotrypsin Leukocyte Elastase Trypsin
  • Primary structure of cathepsin D inhibitor from potatoes and its structure relationship to soybean trypsin inhibitor family Primary structure of cathepsin D inhibitor from potatoes and its structure relationship to soybean trypsin inhibitor family FEBS Lett . 1989 Jul 17;251(1-2):94-8.
  • Overlapping binding sites for trypsin and papain on a Kunitz-type proteinase inhibitor from Prosopis juliflora Overlapping binding sites for trypsin and papain on a Kunitz-type proteinase inhibitor from Prosopis juliflora Proteins . 2002 Nov 15;49(3):335-41.

HMM PROFILE


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GENE MEMBERS DETAILS


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Gene Assembly Chromossome Coordinates SSP Type SSP Family member SignalP D-value Protein Length Annotation
Medtr0084s0030 Mt4.0v1 scaffold0084 16850-17730 known SSP Kunitz1 0.903 202 Kunitz type trypsin inhibitor conf_class=HC
Medtr0100s0150 Mt4.0v1 scaffold0100 33656-34541 known SSP Kunitz2 0.850 201 Kunitz type trypsin inhibitor conf_class=HC
Medtr0211s0080 Mt4.0v1 scaffold0211 25794-26510 known SSP Kunitz3 0.850 198 Kunitz type trypsin inhibitor conf_class=HC
Medtr0302s0030 Mt4.0v1 scaffold0302 14777-15385 known SSP Kunitz4 0.735 202 Kunitz type trypsin inhibitor conf_class=HC
Medtr1g035770 Mt4.0v1 chr1 13071858-13072722 known SSP Kunitz26 0.717 224 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr1g057110 Mt4.0v1 chr1 25083516-25084132 known SSP Kunitz27 0.741 188 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr2g072980 Mt4.0v1 chr2 30871920-30872889 known SSP Kunitz5 0.899 199 Kunitz type trypsin inhibitor conf_class=HC
Medtr2g073010 Mt4.0v1 chr2 30901231-30903185 known SSP Kunitz6 0.831 198 Kunitz type trypsin inhibitor conf_class=HC
Medtr3g014820 Mt4.0v1 chr3 4286399-4287257 known SSP Kunitz7 0.889 203 Kunitz type trypsin inhibitor conf_class=HC
Medtr3g014870 Mt4.0v1 chr3 4294893-4295552 known SSP Kunitz8 0.909 203 Kunitz type trypsin inhibitor conf_class=HC
Medtr3g106585 Mt4.0v1 chr3 49271048-49272286 known SSP Kunitz9 0.862 211 Kunitz type trypsin inhibitor conf_class=HC
Medtr3g106620 Mt4.0v1 chr3 49277351-49278117 known SSP Kunitz10 0.757 213 Kunitz type trypsin inhibitor conf_class=HC
Medtr3g463590 Mt4.0v1 chr3 25494699-25496004 known SSP Kunitz28 0.891 212 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g009563 Mt4.0v1 chr6 2930315-2930944 known SSP Kunitz29 0.688 209 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g009650 Mt4.0v1 chr6 2916699-2917446 known SSP Kunitz30 0.646 210 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g017225 Mt4.0v1 chr6 6868228-6869867 known SSP Kunitz49 0.926 375 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g044780 Mt4.0v1 chr6 15504988-15505954 known SSP Kunitz31 0.766 229 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g044810 Mt4.0v1 chr6 15512193-15513129 known SSP Kunitz32 0.775 218 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g045097 Mt4.0v1 chr6 15984600-15985432 known SSP Kunitz33 0.755 229 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g045403 Mt4.0v1 chr6 16327699-16328382 known SSP Kunitz34 0.692 227 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g045433 Mt4.0v1 chr6 16350987-16351828 known SSP Kunitz35 0.726 223 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g059410 Mt4.0v1 chr6 20400851-20401738 known SSP Kunitz36 0.801 202 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g059530 Mt4.0v1 chr6 20432791-20434050 known SSP Kunitz37 0.824 203 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g059650 Mt4.0v1 chr6 20460270-20461180 known SSP Kunitz38 0.857 211 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g059680 Mt4.0v1 chr6 20475350-20476274 known SSP Kunitz39 0.892 220 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g059730 Mt4.0v1 chr6 20493190-20494222 known SSP Kunitz40 0.905 216 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g059755 Mt4.0v1 chr6 20498927-20499319 known SSP Kunitz41 0.110 130 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g059760 Mt4.0v1 chr6 20502091-20503124 known SSP Kunitz42 0.729 213 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g059810 Mt4.0v1 chr6 20517286-20517927 known SSP Kunitz43 0.844 213 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g065460 Mt4.0v1 chr6 24221657-24222556 known SSP Kunitz44 0.926 207 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g065570 Mt4.0v1 chr6 24275137-24275483 known SSP Kunitz47 0.416 97 kunitz family trypsin and protease inhibitor protein conf_class=LC
Medtr6g066190 Mt4.0v1 chr6 24554668-24555510 known SSP Kunitz45 0.691 217 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g066210 Mt4.0v1 chr6 24566372-24567281 known SSP Kunitz46 0.630 216 Kunitz type trypsin inhibitor / Alpha-fucosidase conf_class=HC
Medtr6g078040 Mt4.0v1 chr6 29317920-29318348 known SSP Kunitz11 0.179 94 kunitz family trypsin and protease inhibitor protein conf_class=LC
Medtr6g078070 Mt4.0v1 chr6 29323018-29323925 known SSP Kunitz12 0.900 203 Kunitz type trypsin inhibitor / miraculin conf_class=HC
Medtr6g078100 Mt4.0v1 chr6 29334587-29335485 known SSP Kunitz13 0.923 205 Kunitz type trypsin inhibitor / miraculin conf_class=HC
Medtr6g078120 Mt4.0v1 chr6 29339427-29340198 known SSP Kunitz14 0.789 213 Kunitz type trypsin inhibitor / miraculin conf_class=HC
Medtr6g078140 Mt4.0v1 chr6 29342602-29343542 known SSP Kunitz15 0.789 213 Kunitz type trypsin inhibitor / miraculin conf_class=HC
Medtr6g078250 Mt4.0v1 chr6 29375539-29376205 known SSP Kunitz16 0.802 204 Kunitz type trypsin inhibitor / miraculin conf_class=HC
Medtr6g078260 Mt4.0v1 chr6 29378378-29378977 known SSP Kunitz17 0.806 199 Kunitz type trypsin inhibitor / miraculin conf_class=HC
Medtr6g078280 Mt4.0v1 chr6 29385612-29386426 known SSP Kunitz18 0.762 212 Kunitz type trypsin inhibitor / miraculin conf_class=HC
Medtr6g078290 Mt4.0v1 chr6 29387667-29389179 known SSP Kunitz19 0.784 213 Lipid transfer protein conf_class=HC
Medtr7g037410 Mt4.0v1 chr7 13787410-13788027 known SSP Kunitz20 0.880 205 Nodule Cysteine-Rich (NCR) secreted peptide conf_class=HC
Medtr7g108815 Mt4.0v1 chr7 44442430-44443124 known SSP Kunitz21 0.765 201 Kunitz type trypsin inhibitor conf_class=HC
Medtr8g059790 Mt4.0v1 chr8 21934174-21934926 known SSP Kunitz22 0.833 204 Kunitz type trypsin inhibitor conf_class=HC
Medtr8g060550 Mt4.0v1 chr8 21403659-21404261 known SSP Kunitz23 0.788 200 Kunitz type trypsin inhibitor conf_class=HC
Medtr8g461050 Mt4.0v1 chr8 21370419-21371027 known SSP Kunitz24 0.775 202 Kunitz type trypsin inhibitor conf_class=HC
Medtr8g461690 Mt4.0v1 chr8 21797953-21798774 known SSP Kunitz25 0.788 200 Kunitz type trypsin inhibitor conf_class=HC
MT35v5_contig_179489_53 Mt3.5v5 contig_179489 3-215 known SSP Kunitz48 0.303 71 Kunitz-type trypsin inhibitor-like 2 protein conf_class=H
MT4Noble_015566 Mt4.0v1 chr3 9797419-9797639 known SSP Kunitz52 0.595 60 Eukaryotic translation initiation factor 2 EIF2-gamma-II
MT4Noble_020906 Mt4.0v1 chr3 49266152-49269724 known SSP Kunitz50 0.799 294 Kunitz type trypsin inhibitor
MT4Noble_040338 Mt4.0v1 chr6 29317488-29320109 known SSP Kunitz51 0.433 91 Eukaryotic translation initiation factor 2 EIF2-gamma-II